The POPPI Trial - results now published!



Society of Critical Care Medicine Annual Congress and

The Journal of the American Medical Association


It is increasingly recognised that high numbers of critically ill patients develop longer-term psychological morbidity following a stay in the critical care unit. POPPI, carried out in 24 UK critical care units and which included 1,458 critically ill patients, set out to evaluate whether an early, nurse-led, preventive, complex psychological intervention reduces the development of patient-reported post-traumatic stress disorder symptom severity at six months.

We can confirm that the results of POPPI were presented by Professor Kathy Rowan on 18 February 2019 at the Society of Critical Care Medicine (SCCM) 48th Annual Congress in San Diego, United States. Simultaneously, the results were published online in the Journal of the American Medical Association (JAMA) – the article can be viewed on the JAMA website at the following link:

https://jamanetwork.com/journals/jama/fullarticle/2725208

POPPI - led by Professor Rowan as Chief Investigator - was funded by the National Institute for Health Research – Health Services & Delivery Research Programme and is a collaboration between researchers and clinicians from ICNARC, The London School of Hygiene and Tropical Medicine and University College London Hospitals NHS Foundation Trust.

We would like to say a big thanks to all of the patients who took their time to participate in this trial. We also thank our participating sites, and in particular our dedicated POPPI nurses, for their commitment and enthusiasm, without which this trial would not have been possible.

Published: 21 February 2019


POPPI was funded by the National Institute for Health Research (NIHR) Health Services and Delivery Research (HS&DR) Programme (project number: 12/64/124). The views and opinions expressed therein are those of the authors and do not necessarily reflect those of the HS&DR Programme, NIHR, NHS or the Department of Health.

  • Authors: Sadique Z, Grieve R, Diaz-Ordaz K, Mouncey P, Lamontagne F, O'Neill S Title: A Machine-Learning Approach for Estimating Subgroup- and Individual-Level Treatment Effects: An Illustration Using the 65 Trial Publication: Medical Decision Making Journal website PubMed citation
  • Authors: Mouncey PR, Richards-Belle A, Thomas K, Harrison DA, Sadique MZ, Grieve RD, Camsooksai J, Darnell R, Gordon AC, Henry D, Hudson N, Mason A J, Saull M, Whitman C, Young JD, Lamontagne F, Rowan KM Title: Reduced exposure to vasopressors through permissive hypotension to reduce mortality in critically ill people aged 65 and over: the 65 RCT Publication: Health Technology Assessment Journal website PubMed citation
  • Authors: Lamontagne F, Richards-Belle A, Thomas K, Harrison DA, Sadique MZ, Grieve RD, Camsooksai J, Darnell R, Gordon AC, Henry D, Hudson N, Mason AJ, Saull M, Whitman C, Young DJ, Rowan KM, Mouncey PR, 65 Trial Investigators Title: Effect of Reduced Exposure to Vasopressors on 90-Day Mortality in Older Critically Ill Patients With Vasodilatory Hypotension: A Randomized Clinical Trial Publication: JAMA Journal website PubMed citation
  • Authors: Richards-Belle A, Mouncey PR, Grieve RD, Harrison DA, Sadique MZ, Henry D, Whitman C, Camsooksai J, Gordon AC, Young DJ, Rowan KM, Lamontagne F Title: Evaluating the clinical and cost-effectiveness of permissive hypotension in critically ill patients aged 65 years or over with vasodilatory hypotension: Protocol for the 65 randomised clinical trial Publication: Journal of the Intensive Care Society Journal website
  • Authors: Thomas K, Patel A, Sadique Z, Grieve RD, Mason AJ, Moler S, Gordon AC, Rowan KM, Mouncey PR, Lamontagne F, Harrison DA; on behalf of the 65 trial investigators Title: Evaluating the clinical and cost-effectiveness of permissive hypotension in critically ill patients aged 65 years or over with vasodilatory hypotension: Statistical and Health Economic Analysis Plan for the 65 trial Publication: Journal of the Intensive Care Society Journal website

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