Advisory

Supporting external research studies

ICNARC provides support to external research studies by providing independent members for Trial Steering Committees and Data Monitoring & Ethics Committees.

Trial/Study Steering Committees:

• Beta Agonist Lung Injury Trial 2 (BALTI-2) – a multicentre UK study into the effects of an intravenous infusion of salbutamol on the 28 day outcome of ventilated patients with ARDS, University of Warwick
• Protocolised Trial of Invasive and Non-invasive Weaning Off Ventilation (Breathe), Intensive Care Foundation/University of Warwick
• ECCO2R Evaluation, Birmingham & Brunel Consortium
• Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in acute lung injury to Reduce Pulmonary dysfunction (HARP 2), Clinical Research Support Centre, Royal Group of Hospitals Trust, Belfast
• Conventional positive pressure ventilation or High Frequency Oscillatory Ventilation (HFOV) for adults with acute respiratory distress syndrome (OSCAR), Intensive Care Society Trials Group/University of Oxford

Data Monitoring & Ethics Committees:

• Scandinavian Starch for Severe Sepsis/Septic Shock Trial (6S)
• Protocolised Trial of Invasive and Non-invasive Weaning Off Ventilation (Breathe) 
• Control of Hyperglycaemia in Paediatric Intensive Care (CHiP) 
• Fibrinogen concentrate supplementation in the management of bleeding during paediatric cardiopulmonary bypass (FIBCON)
• Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in Acute lung injury to Reduce Pulmonary dysfunction (HARP 2)
• Prehospital Randomised Assessment of a Mechanical compression Device In Cardiac arrest (PaRAMeDIC) 
• Prophylaxis of Thromboembolism in Critically Ill Patients Using Combined Intermittent Pneumatic Compression and Pharmacologic Prophylaxis Versus Pharmacologic Prophylaxis Alone (PREVENT)

Other Groups/Committees

We contribute to critical and emergency care research more broadly through membership of:

• Health Services Research Network (HSRN)
• Intensive Care Society Research Committee 
• International Forum for Acute Care Trialists (InFACT) 
• International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) 
• NIHR CRN Critical Care Specialty Group 
• The Liverpool Care Pathway for the Dying Patient, Continuous Quality Improvement Programme, University of Liverpool
• UK Critical Care Research Forum (UKCCRF)
• UKCRC Registered Clinical Trials Units Network